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Systematic (IUPAC) name
CAS number 24219-97-4
ATC code N06AX03
PubChem 4184
Chemical data
Formula C18H20N2 
Mol. mass 264.365
Pharmacokinetic data
Bioavailability  ?
Metabolism  ?
Half life  ?
Excretion  ?
Therapeutic considerations
Pregnancy cat.


Legal status
Routes  ?

Mianserin is a tetracyclic antidepressant that has antihistaminic and hypnosedative, but almost no anticholinergic, effect. Mianserin is a weak inhibitor of norepinephrine reuptake and strongly stimulates the release of norepinephrine. Interactions with serotonin receptors in the central nervous system have also been found. Its effect is usually noticeable after one to three weeks. It was previously available internationally, however in most markets it has been phased out in favor of Mirtazapine.

Mianserin blocks inhibitory α2-autoreceptors on central noradrenergic nerve endings, and so may increase the amount of noradrenaline in the synaptic cleft. It may also cause agranulocytosis and aplastic anaemia.

Mianserin has been shown to increase the lifespan of the nematode C. elegans by 30%.[1] [2]


  1. ^ Antidepressant Found To Extend Lifespan In C. elegans
  2. ^ An antidepressant that extends lifespan in adult Caenorhabditis elegans
This article is licensed under the GNU Free Documentation License. It uses material from the Wikipedia article "Mianserin". A list of authors is available in Wikipedia.
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