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Promazine



Promazine
Systematic (IUPAC) name
N,N-dimethyl-3-(10H-phenothiazin-10-yl) propan-1-amine
Identifiers
CAS number	58-40-2
ATC code	N05AA03
PubChem	4926
DrugBank	APRD00358
Chemical data
Formula	C₁₇H₂₀N₂S
Mol. mass	284.42 g/mol
Pharmacokinetic data
Bioavailability	?
Protein binding	94%
Metabolism	?
Half life	?
Excretion	?
Therapeutic considerations
Pregnancy cat.	?
Legal status
Routes	?

Promazine (marketed as Sparine) is a medication that belongs to the phenothiazine class of antipsychotics. An older medication used to treat schizophrenia, its use has largely been replaced by newer agents such as olanzapine and quetiapine.

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It has predominantly anticholinergic side effects, though extrapyramidal side effects are not uncommon either.

v • d • e Psycholeptics: antipsychotics (N05A)
Phenothiazine typical antipsychotics	Chlorpromazine • Fluphenazine • Mesoridazine • Perphenazine • Prochlorperazine • Promazine • Thioridazine/Sulforidazine • Trifluoperazine
Other typical antipsychotics	Indoles (Molindone) • Butyrophenones (Azaperone, Benperidol, Droperidol, Haloperidol, Trifluperidol) • Thioxanthenes (Flupentixol, Chlorprothixene, Thiothixene, Zuclopenthixol) • diphenylbutylpiperidines (Fluspirilene, Penfluridol, Pimozide) • other (Loxapine)
Atypical antipsychotics	Butyrophenones (Melperone) • Indoles (Sertindole, Ziprasidone) • Benzamides (Sulpiride, Remoxipride, Amisulpride) • diazepines/oxazepines/thiazepines (Clozapine, Olanzapine, Quetiapine) • other (Aripiprazole, Risperidone, Paliperidone, Asenapine, Iloperidone, Zotepine)