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IUPAC name 1-cyclohexylbutan-1-one
CAS number
PubChem 10315
Molecular formula C10H12O
Molar mass 148.202
Except where noted otherwise, data are given for
materials in their standard state
(at 25 °C, 100 kPa)

Infobox disclaimer and references

Butyrophenone is a chemical compound (a ketone); some of its derivatives (called commonly butyrophenones) are used to treat various psychiatric disorders such as schizophrenia, as well as acting as antiemetics.

Butyrophenones are a class of pharmaceutical drugs derived from butyrophenone.

Examples include:

  • Haloperidol, the most widely-used drug in this class
  • Droperidol, often used for neuroleptanalgesic anesthesia and sedation in intensive-care treatment
  • Benperidol, the most potent commonly-used antipsychotic (~ 200 times more potent as chlorpromazine)
  • Triperidol, a highly-potent antipsychotic (100 times more potent than chlorpromazine)
  • Melperone, a weakly-potent antipsychotic, in Europe commonly used for treatment of insomnia, confusional states, psychomotor agitation, and delirium, in particular, in geriatric patients
  • Lenperone
  • Domperidone, an dopamine-antagonist antiemetic, derived further from butyrophenone (not being a butyrophenone itself).

The atypical antipsychotic risperidone, although not a butyrophenone, was developed with the structures of benperidol and lenperone as a basis.

This article is licensed under the GNU Free Documentation License. It uses material from the Wikipedia article "Butyrophenone". A list of authors is available in Wikipedia.
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