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Cefoxitin



Cefoxitin
Systematic (IUPAC) name
(6S,7R)-4-(carbamoyloxymethyl)-7-methoxy-
8-oxo-7-[(2-thiophen-2-ylacetyl)amino]-5-thia-
1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid
Identifiers
CAS number 35607-66-0
ATC code J01DC01
PubChem 37194
Chemical data
Formula C16H17N3O7S2 
Mol. mass 427.454 g/mol
Pharmacokinetic data
Bioavailability  ?
Metabolism minimal
Half life 41-59 min
Excretion 85% urine
Therapeutic considerations
Pregnancy cat.

B

Legal status
Routes IV

Cefoxitin is a cephamycin antibiotic often grouped with the second−generation cephalosporins. It is also known as Mefoxin.

Additional recommended knowledge

Microbiology

Cefoxitin acts by interfering with cell wall synthesis. Its activity spectrum includes a broad range of gram-negative and gram-positive bacteria including anaerobes. It is inactive in vitro to most strains of Pseudomonas aeruginosa and enterococci and many strains of Enterobacter cloacae. Staphlococci resistant to methicillin/oxacillin should be considered resistant to cefoxitin. [1]

References

  1. ^ Mefoxin Official FDA information at Drugs.com


 
This article is licensed under the GNU Free Documentation License. It uses material from the Wikipedia article "Cefoxitin". A list of authors is available in Wikipedia.
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