17-Mar-2009 - NanoSight Ltd.

National Physical Laboratory to Evaluate NanoSight

The UK’s national metrology institute, the National Physical Laboratory (NPL), is commencing a one-year evaluation program of NanoSight’s nanoparticle characterization technology, Nanoparticle Tracking Analysis (NTA).

The program takes the form of a Joint Industry Project, funded in part by government. The initial objective is a validation of NTA and comparison with existing nanoparticle sizing techniques and standards.

Dr Alex Cuenat, NPL’s Nanomaterials Group Leader, reports: “What differentiates NanoSight from existing light scattering techniques is that it provides a direct view of the sample under analysis and rapid quantitative estimation of the sample size, size distribution and concentration.

“No method is truly universal. Most ensemble measurements are made using dynamic light scattering (DLS) or photon correlation spectroscopy (PCS). These methods are very fast with thousands of particles analysed in a single second but they cannot accurately analyze multi-modal (more than one size) dispersions or follow changes during analysis.

“NanoSight’s Nanoparticle Tracking Analysis (NTA) differs in that it measures particle speed compared to DLS which is measuring intensity of light scattered. This unique real-time capability to follow the Brownian motion of individual nano-particles, leads to advantages over DLS. These include avoidance of a bias towards larger particles, which is driven by the latter’s dependence on scatter intensity; an estimate of concentration which NanoSight provides; and a unique image validating the results and providing additional insight.

“We first saw a NanoSight prototype in 2005 and recognised how, with development, the technique had potential to fill gaps in characterization methodologies of sub-micron dispersions. Since then, we have seen this technique develop well, so, although we do not know yet how this will result, we are enthusiastic about running an in-depth validation. This investigation will look at precision and accuracy and assess the validity of the algorithms used in NTA in some depth.”

Facts, background information, dossiers
More about NanoSight
More about National Physical Laboratory
  • News

    New test detects drug use from a single fingerprint

    Led by the University of Surrey, a team of researchers from the Netherlands Forensic Institute (NL), the National Physical Laboratory (UK), King’s College London (UK) and Sheffield Hallam University (UK), used different types of an analytical chemistry technique known as mass spectrometry t ... more

    On the edge of graphene

    Researchers at the National Physical Laboratory (NPL) have discovered that the conductivity at the edges of graphene devices is different to that of the central material. Local scanning electrical techniques were used to examine the local nanoscale electronic properties of epitaxial graphen ... more

    Quantum model helps solve mysteries of water

    A research team from the National Physical Laboratory (NPL), the University of Edinburgh and IBM's TJ Watson Research Center has revealed a major breakthrough in the modelling of water that could shed light on its mysterious properties. Water is one of the most common and extensively studie ... more

  • Videos

    The Watt balance and redefining the kilogram

    Video by the National Physical Laboratory (NPL) with Dr Bryan Kibble, Dr Tony Hartland and Dr Ian Robinson more