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Oxaprozin



Oxaprozin
Systematic (IUPAC) name
3-(4,5-diphenyl-1,3-oxazol-2-yl)propanoic acid
Identifiers
CAS number 21256-18-8
ATC code M01AE12
PubChem 4614
DrugBank APRD00030
Chemical data
Formula C18H15NO3 
Mol. mass 293.317 g/mol
Pharmacokinetic data
Bioavailability 95%
Protein binding 99%
Metabolism Liver—65% oxidation and 35% glucuronic acid conjugation. 5% are active phenolic metabolites.
Half life 54.9 hours
Excretion  ?
Therapeutic considerations
Pregnancy cat.

C

Legal status
Routes Oral

Oxaprozin (brand name: Daypro) is a non-narcotic, non-steroidal anti-inflammatory drug (NSAID), used to relieve the inflammation, swelling, stiffness, and joint pain associated with osteoarthritis and rheumatoid arthritis. Chemically, it is a propionic acid derivative. It is available in 600 mg tablets. Normal adult dosage is 1200 mg daily, not to exceed 1800 mg per day. Safety and efficacy has been established in children over 6 years with juvenile rheumatoid arthritis only, and there is an increased risk of adverse reactions in the elderly population.


 
This article is licensed under the GNU Free Documentation License. It uses material from the Wikipedia article "Oxaprozin". A list of authors is available in Wikipedia.
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