My watch list
my.chemeurope.com  
Login  

Lofendazam



Lofendazam
Systematic (IUPAC) name
8-chloro-1-phenyl-4,5-dihydro-3H-1,5-benzodiazepin-2-one
Identifiers
CAS number 29176-29-2
ATC code  ?
PubChem 71709
Chemical data
Formula C15H13ClN2O 
Mol. mass 272.73
Pharmacokinetic data
Bioavailability  ?
Metabolism  ?
Half life  ?
Excretion  ?
Therapeutic considerations
Pregnancy cat.

?

Legal status
Routes  ?

Lofendazam is a drug which is a benzodiazepine derivative. Lofendazam is a 1,5-benzodiazepine, with the nitrogen atoms located at positions 1 and 5 of the diazepine ring, and so is most closely related to other 1,5-benzodiazepines such as clobazam. [1][2]

Additional recommended knowledge

Lofendazam has sedative and anxiolytic effects similar to those produced by other benzodiazepine derivatives. It is an active metabolite of another benzodiazepine, arfendazam.[3]



References

  1. ^ Malik F, Hasan M, Khan KM, Perveen S, Snatzke G, Duddeck H, Voelter W. Syntheses and CD studies of optically active substituted 1,3,4,5-tetrahydro-2H-1,5-benzodiazepin-2-ones. Liebigs Annalen der Chemie, 1995. (10):1861-1869.
  2. ^ Aversa MC, Giannetto P, Romeo G, Ficarra P, Vigorita MG. Nuclear magnetic resonance spectra of psychotherapeutic agents. V* - conformational analysis of 1,3,4,5-tetrahydro-2H-1,5-benzodiazepin-2-ones. Organic Magnetic Resonance, 1981. 15(4):394-398
  3. ^ J. Adrien, F. Albani, A. Baruzzi, M. Berger, E.O. Bixler, A.A. Borbeley, D.G. Dikeos, R. Drucker-Colin, R. Fritsch Montero, Y. Hishikawa, S. Inoue, A. Kales, E. Lugaresi, H. Merchant-Nancy, J.M. Monti. The Pharmacology of Sleep. Springer. ISBN 978-3540589617
 
This article is licensed under the GNU Free Documentation License. It uses material from the Wikipedia article "Lofendazam". A list of authors is available in Wikipedia.
Your browser is not current. Microsoft Internet Explorer 6.0 does not support some functions on Chemie.DE