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Systematic (IUPAC) name
2-(2-chlorophenyl)-9-ethyl-6-methyl- 8-thia-3,6-diazabicyclo[5.3.0]deca-2,9,11-trien-5-one
CAS number 33671-46-4
ATC code N05BA21
PubChem 2811
DrugBank ?
Chemical data
Formula C16H15ClN2OS 
Mol. mass 318.8 g/mol
Pharmacokinetic data
Bioavailability  ?
Metabolism Hepatic
Half life  ?
Excretion Renal
Therapeutic considerations
Pregnancy cat.


Legal status

Schedule IV(US)

Routes Oral

Clotiazepam (marketed under brand name Trecalmo) is a drug which is a benzodiazepine derivative. It possesses anxiolytic, anticonvulsant, sedative and skeletal muscle relaxant properties. Stage 2 NREM sleep is significantly increased by clotiazepam.[1]

Clotiazepam is not approved for sale in the United States or Canada.


  1. ^ Nakazawa Y; Kotorii M, Oshima M, Horikawa S, Tachibana H. (31). "Effects of thienodiazepine derivatives on human sleep as compared to those of benzodiazepine derivatives.". Psychopharmacologia. 44 (2): 165-71. PMID 709.
This article is licensed under the GNU Free Documentation License. It uses material from the Wikipedia article "Clotiazepam". A list of authors is available in Wikipedia.
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