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Systematic (IUPAC) name
7-bromo-5-(2-chlorophenyl)-2-(methoxymethyl) -1-methyl-2,3-dihydro-1,4-benzodiazepine
CAS number 84031-17-4
ATC code  ?
PubChem 71272
Chemical data
Formula C18H18BrClN2O 
Mol. mass 393.705
Pharmacokinetic data
Bioavailability  ?
Metabolism  ?
Half life  ?
Excretion  ?
Therapeutic considerations
Pregnancy cat.


Legal status
Routes  ?

Metaclazepam (Talis) is a drug which is a benzodiazepine derivative. It is a relatively selective anxiolytic with less sedative or muscle relaxant properties than other benzodiazepines such as diazepam or bromazepam.[1]

Metaclazepam is slightly more effective as an anxiolytic than bromazepam,[2] or diazepam,[3] with a 15mg dose of metaclazepam equivalent to 4mg of bromazepam.[4]


  1. ^ Buschmann G, Kuhl UG, Rohte O. General pharmacology of the anxiolytic compound metaclazepam in comparison to other benzodiazepines. Arzneimittelforschung. 1985;35(11):1643-55.
  2. ^ Bilone F, Roncari R. A double-blind comparison of the anxiolytic activity of two benzodiazepines, metaclazepam and bromazepam, in anxiety neurosis. Current Medical Research and Opinion. 1988;11(1):45-7.
  3. ^ Laakmann G, Blaschke D, Hippius H, Schewe S. Double-blind study of metaclazepam versus diazepam treatment of outpatients with anxiety syndrome. Pharmacopsychiatry. 1989 May;22(3):120-5.
  4. ^ Marano P, Patti F, Nicoletti F. Controlled study on the anxiolytic activity of a newly-developed benzodiazepine, metaclazepam. Current Medical Research and Opinion. 1988;11(1):41-4.
This article is licensed under the GNU Free Documentation License. It uses material from the Wikipedia article "Metaclazepam". A list of authors is available in Wikipedia.
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