My watch list
my.chemeurope.com  
Login  

Flutazolam



Flutazolam
Systematic (IUPAC) name
10-chloro-11b-(2-fluorophenyl)-7-(2-hydroxyethyl) -3,5-dihydro-2H-[1,3]oxazolo[3,2-d][1,4]benzodiazepin-6-one
Identifiers
CAS number 27060-91-9
ATC code  ?
PubChem 3398
Chemical data
Formula C19H18ClFN2O3 
Mol. mass 376.809
Pharmacokinetic data
Bioavailability  ?
Metabolism  ?
Half life  ?
Excretion  ?
Therapeutic considerations
Pregnancy cat.

?

Legal status
Routes  ?

Flutazolam (Coreminal, MS-4101) is a drug which is a benzodiazepine derivative. It was invented in Japan, and this is the main country in which it has been used medically. It has sedative and anxiolytic effects similar to those produced by other benzodiazepine derivatives, and is around the same potency as diazepam.[1]

Additional recommended knowledge

Flutazolam is closely related in structure to another benzodiazepine, haloxazolam.[2][3]




References

  1. ^ Mitsushima T, Ueki S. Psychopharmacological effects of flutazolam (MS-4101). Nippon Yakurigaku Zasshi. 1978 Nov;74(8):959-79. (Japanese).
  2. ^ Kuwayama T, Kurono Y, Muramatsu T, Yashiro T, Ikeda K. The behavior of 1,4-benzodiazepine drugs in acidic media. V. Kinetics of hydrolysis of flutazolam and haloxazolam in aqueous solution. Chemical and Pharmaceutical Bulletin (Tokyo). 1986 Jan;34(1):320-6.
  3. ^ Yashiro T, Kuwayama T, Kawazura H, Suzuki T. The behavior of 1,4-benzodiazepine drugs in acidic media. IX. Effect of hydrolyzate of flutazolam on the central nervous system. Journal of the Pharmaceutical Society of Japan. 1987 Oct;107(10):830-4. (Japanese).
 
This article is licensed under the GNU Free Documentation License. It uses material from the Wikipedia article "Flutazolam". A list of authors is available in Wikipedia.
Your browser is not current. Microsoft Internet Explorer 6.0 does not support some functions on Chemie.DE