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Phenazepam



Phenazepam
Systematic (IUPAC) name
7-bromo-5-(2-chlorophenyl)-1,3-dihydro

-1,4-benzodiazepin-2-one

Identifiers
CAS number 51753-57-2
ATC code  ?
PubChem 40113
Chemical data
Formula C15H10BrClN2O 
Mol. mass 349.609
Pharmacokinetic data
Bioavailability  ?
Metabolism  ?
Half life  ?
Excretion  ?
Therapeutic considerations
Pregnancy cat.

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Legal status
Routes  ?

Phenazepam is a benzodiazepine drug, which was developed in Soviet Union and now produced in Russia and some CIS countries. Phenazepam is used in the treatment of neurological disorders such as epilepsy, alcohol withdrawal and insomnia. It can be used as a premedication before surgery as it augments the effects of anesthetics and reduces anxiety.

Additional recommended knowledge

Contents

Dosage

An average phenazepam dosage is 0.5 mg 2-3 times daily. The maximum daily dosage must not exceed 10 mg.

Side effects

Side effects include dizziness, loss of coordination, drowsiness. As with other sedatives, in case of abrupt discontinuation following prolonged use, severe withdrawal symptoms may occur.

Legal Status

Phenazepam does not appear in the list of Controlled Substances in the Laws of either the USA or the UK, where in each country, benzodiazepines are generally Class C, Schedule IV substances. Like all benzodiazepines, it is legally classified as a C-IV substance in accordance with the analogue act in the U.S. (Flunitrazepam, aka "rohypnol", is dually scheduled.)

According to the official investigation report, effects of phenazepam on pilot Pavel Gruzin may have contributed to errors that caused the crash of Crossair Flight 498.[1]

References

  1. ^ Investigation Report of the Aircraft Accident Investigation Bureau on the accident to the Saab 340B aircraft, registration HB-AKK of Crossair Flight LX498 on 10 January 2000 near Nassenwil/ZH.

CAS number 66173-95-3

 
This article is licensed under the GNU Free Documentation License. It uses material from the Wikipedia article "Phenazepam". A list of authors is available in Wikipedia.
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