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NK1 receptor antagonist



Neurokinin NK1 antagonists are a novel class of medications that possesses unique antidepressant[1], anxiolytic[2], and antiemetic properties.

The NK2 and NK3 receptors are also targets for novel classes of medications, and also show prominent antidepressive and anxiolytic effects.[3]

See also

  • Tachykinin receptor

References

  1. ^ Varty GB, Cohen-Williams ME, Hunter JC (2003). "The antidepressant-like effects of neurokinin NK1 receptor antagonists in a gerbil tail suspension test". Behavioural pharmacology 14 (1): 87-95. doi:10.1097/01.fbp.0000055962.09493.e9. PMID 12576885.
  2. ^ Varty GB, Cohen-Williams ME, Morgan CA, et al (2002). "The gerbil elevated plus-maze II: anxiolytic-like effects of selective neurokinin NK1 receptor antagonists". Neuropsychopharmacology 27 (3): 371-9. doi:10.1016/S0893-133X(02)00313-5. PMID 12225694.
  3. ^ Salomé N, Stemmelin J, Cohen C, Griebel G (2006). "Selective blockade of NK2 or NK3 receptors produces anxiolytic- and antidepressant-like effects in gerbils". Pharmacol. Biochem. Behav. 83 (4): 533-9. doi:10.1016/j.pbb.2006.03.013. PMID 16624395.


v • d • e
Psychoanaleptics: antidepressants (N06A)
MAOIsIproclozide • Iproniazid • Isocarboxazid • Nialamide • Pargyline • Phenelzine • Rasagiline • Selegiline • Toloxatone • Tranylcypromine
RIMAs: Brofaromine • Beta-carbolines (Harmaline) • Moclobemide
RIs
S RI SS RI (Alaproclate, Citalopram, Dapoxetine, Escitalopram, Etoperidone, Fluoxetine, Fluvoxamine, Paroxetine, Sertraline, Zimelidine)
• TCAs/Tetras (Clomipramine, Nefazodone, Trazodone)
N RI / A RI Atomoxetine • Maprotiline • Reboxetine • Viloxazine • TCAs/Tetras (Amitriptyline, Amoxapine, Butriptyline, Desipramine/Lofepramine, Dibenzepin, Dothiepin, Doxepin, Imipramine, Iprindole, Melitracen, Nortriptyline, Opipramol, Protriptyline, Trimipramine, Maprotiline)
D RI Vanoxerine • Phenmetrazine • TCAs (Amineptine)
SN RI Bicifadine • Desvenlafaxine • Duloxetine • Milnacipran • Nefazodone • Venlafaxine
ND RI Bupropion
SND RI Brasofensine • Tesofensine • Nomifensine
SSREsTianeptine
AAsTetras (Mianserin, Mirtazapine)
v • d • e
Antiemetics and antinauseants (A04)
Serotonin (5-HT3) antagonistsOndansetron • Granisetron • Tropisetron • Dolasetron • Palonosetron
OtherScopolamine • Cerium oxalate • Chlorobutanol • Metopimazine • Cannabinoids (Dronabinol, Nabilone) • NK1 receptor antagonist (Aprepitant)
 
This article is licensed under the GNU Free Documentation License. It uses material from the Wikipedia article "NK1_receptor_antagonist". A list of authors is available in Wikipedia.
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