Interleukin 18 (interferon-gamma-inducing factor)
| Solution structure of human IL-18
| Available structures: 1j0s
|| IL18; IGIF; IL-18; IL-1g; IL1F4; MGC12320
| External IDs
|| OMIM: 600953 MGI: 107936 Homologene: 1200
| Molecular Function:
|| • signal transducer activity|
• interleukin-1 receptor binding
| Cellular Component:
|| • extracellular region|
• extracellular space
| Biological Process:
|| • angiogenesis|
• immune response
• cell-cell signaling
• induction of apoptosis via death domain receptors
• regulation of cell adhesion
• chemokine biosynthetic process
• T-helper 1 type immune response
• T-helper 2 type immune response
• interleukin-2 biosynthetic process
• interferon-gamma biosynthetic process
• positive regulation of activated T cell proliferation
• interleukin-13 biosynthetic process
• granulocyte macrophage colony-stimulating factor biosynthetic process
| RNA expression pattern
Additional recommended knowledge
More reference expression data
|| NM_001562 (mRNA)|
|| Chr 11: 111.52 - 111.54 Mb
|| Chr 9: 50.33 - 50.33 Mb
| Pubmed search
Interleukin-18 (IL-18) is a cytokine produced by macrophages and other cells that belongs to the IL-1 superfamily. IL-18 works together with IL-12 to induce cell-mediated immunity following infection with microbial products like lipopolysaccharide (LPS). After stimulation with IL-18, natural killer (NK) cells and certain T cells release another important cytokine called interferon-γ (IFN-γ) or type II interferon that plays an important role in activating the macrophages or other cells. Apart from its physiological role, IL-18 is also able to induce severe inflammatory reactions, which suggests its role in certain inflammatory disorders.
The protein encoded by this gene is a proinflammatory cytokine. This cytokine can induce the IFN-gamma production of T cells. The combination of this cytokine and IL12 has been shown to inhibit IL4 dependent IgE and IgG1 production, and enhance IgG2a production of B cells. IL-18 binding protein (IL18BP) can specifically interact with this cytokine, and thus negatively regulate its biological activity.
- ^ Entrez Gene: IL18 interleukin 18 (interferon-gamma-inducing factor).
- Biet F, Locht C, Kremer L (2002). "Immunoregulatory functions of interleukin 18 and its role in defense against bacterial pathogens.". J. Mol. Med. 80 (3): 147-62. doi:10.1007/s00109-001-0307-1. PMID 11894141.
- Nakanishi K (2002). "[Regulation of Th1 and Th2 immune responses by IL-18]". Kekkaku 77 (2): 87-93. PMID 11905033.
- Reddy P, Ferrara JL (2003). "Role of interleukin-18 in acute graft-vs-host disease.". J. Lab. Clin. Med. 141 (6): 365-71. doi:10.1016/S0022-2143(03)00028-3. PMID 12819633.
- Kanai T, Uraushihara K, Totsuka T, et al. (2003). "Macrophage-derived IL-18 targeting for the treatment of Crohn's disease.". Current drug targets. Inflammation and allergy 2 (2): 131-6. PMID 14561165.
- Matsui K, Tsutsui H, Nakanishi K (2005). "Pathophysiological roles for IL-18 in inflammatory arthritis.". Expert Opin. Ther. Targets 7 (6): 701-24. doi:10.1517/1472818.104.22.1681. PMID 14640907.
- Yoshimoto T, Nakanishi K (2006). "Roles of IL-18 in basophils and mast cells.". Allergology international : official journal of the Japanese Society of Allergology 55 (2): 105-13. doi:10.2332/allergolint.55.105. PMID 17075246.
- Orozco A, Gemmell E, Bickel M, Seymour GJ (2007). "Interleukin 18 and periodontal disease.". J. Dent. Res. 86 (7): 586-93. PMID 17586702.