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Interleukin 27



Interleukin 27
Identifiers
Symbol IL27
Alt. Symbols , IL30, p28
Entrez 246778
HUGO 19157
OMIM 608273
RefSeq NM_145659
UniProt Q6P676
Other data
Locus Chr. 16 p11
Interleukin 27B
Identifiers
Symbol IL27B
Alt. Symbols EBI3
HUGO 3129
OMIM 605816
UniProt Q14213
Other data


Interleukin-27 (IL-27) is a heterodimeric cytokine belonging to the IL-12 family that is composed of two subunits, Epstein-Barr virus (EBV)-induced gene 3 (EBI3) (also known as IL-27B) and IL27-p28 (also called IL-28).[1] IL-27 plays an important function in regulating the activity of B and T lymphocytes.[2] The effects of IL-27 are eliciting by its interaction with a specific cell surface receptor complex composed of two proteins known as IL-27R and gp130. The gene symbol IL27 refers to the IL-30 subunit of IL-27.[3]

Additional recommended knowledge

References

  1. ^ F. Larousserie et al., Analysis of Interleukin-27 (EBI3/p28) Expression in Epstein-Barr Virus- and Human T-Cell Leukemia Virus Type 1-Associated Lymphomas Heterogeneous Expression of EBI3 Subunit by Tumoral Cells, American Journal of Pathology, 2005, Volume 166, pages 1217-1228.
  2. ^ F. Larousserie et al., Differential Effects of IL-27 on Human B Cell Subsets. Journal of Immunology, 2006, Volume 176, pages 5890-5897.
  3. ^ http://www.gene.ucl.ac.uk/nomenclature/data/get_data.php?hgnc_id=19157



 
This article is licensed under the GNU Free Documentation License. It uses material from the Wikipedia article "Interleukin_27". A list of authors is available in Wikipedia.
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