| Alt. Symbols
|| , IL-25
| Other data
|| Chr. 14 q11.2
Interleukin-25 (IL-25) is a cytokine that belongs to the IL-17 cytokine family and is secreted by type 2 helper T cells (Th2) and mast cells. It is also known as IL-17E. IL-25 induces the production of other cytokines, including IL-4, IL-5 and IL-13 in multiple tissues, which stimulate the expansion of eosinophils. This cytokine is an important molecule controlling immunity of the gut and has been implicated in chronic inflammation associated with the gastrointestinal tract. Further, the IL-25 gene has been identified in a chromosomal region associated with autoimmune diseases of the gut such as inflammatory bowel disease (IBD), although no direct evidence suggests that IL-25 plays any role in this disease.
Additional recommended knowledge
- ^ Kei Ikeda et al., Mast cells produce interleukin-25 upon FcRI-mediated activation, Blood, 2003, Volume 101, pages 3594-3596.
- ^ The HGNC site for IL-25
- ^ Owyang et al., Interleukin 25 regulates type 2 cytokine-dependent immunity and limits chronic inflammation in the gastrointestinal tract, Journal of Experimental Medicine, 2006, Volume 203, 843-849.
- ^ Buning et al., The interleukin-25 gene located in the inflammatory bowel disease (IBD) 4 region: no association with inflammatory bowel disease. European Journal of Immunogenetics, 2003, Volume 30, pages 329-333
Identification of an interleukin (IL)-25–dependent cell population that provides IL-4, IL-5, and IL-13 at the onset of helminth expulsion, http://www.jem.org/cgi/content/abstract/203/4/1105