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Interleukin 31

Interleukin 31
Symbol IL31
Entrez 386653
HUGO 19372
OMIM 609509
RefSeq NM_001014336
UniProt Q6EBC2
Other data
Locus Chr. 12 q24.31

Interleukin-31 (IL-31) is a cytokine with a four-helix bundle structure, which is preferentially produced by type 2 helper T cells (Th2). The structure of IL-31 places it in the IL-6 family of cytokines. IL-31 signals via a receptor complex that is composed of IL-31 receptor A (IL-31RA) and oncostatin M receptor subunits. These receptor subunits are expressed in activated monocytes and in unstimulated epithelial cells. IL-31 is believed to play a role in inflammation of the skin.[1]


  1. ^ Stacey R Dillon et al., Interleukin 31, a cytokine produced by activated T cells, induces dermatitis in mice., Nature Immunology, 2004, Volume 5, pages 752-760.

This article is licensed under the GNU Free Documentation License. It uses material from the Wikipedia article "Interleukin_31". A list of authors is available in Wikipedia.
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