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Interleukin 14



Interleukin 14
Identifiers
Symbol TXNLA
Alt. Symbols HMW-BCGF, IL14
Entrez 3599
HUGO 5976
OMIM 608676
RefSeq NP_787048
UniProt L15344
Other data
Locus Chr. 1 p34.3

Interleukin-14 (IL-14) is a cytokine that is also called High molecular weight B-cell growth factor (HMW-BCGF) that controls the growth and proliferation of both normal and cancerous B cells.[1] This molecule was also recently designated taxilin.[2] IL-14 induces B-cell proliferation, inhibits antibody secretion, and expands selected B-cell subgroups. This interleukin is produced mainly by T cells and certain malignant B cells.

Additional recommended knowledge

Two distinct transcripts are produced from opposite strands of the il14 gene that are called IL-14α and IL-14β.[3] The il14 locus is near the gene for LCK on chromosome 1 in humans.

References

  1. ^ Ambrus JL et al., Identification of a cDNA for a human high-molecular-weight B-cell growth factor., 1993, Proceedings of the National Academy of Sciences USA, Volume 90, pages 6330-4.
  2. ^ Nogami,S et al., Taxilin; a novel syntaxin-binding protein that is involved in Ca2+- dependent exocytosis in neuroendocrine cells. Genes Cells, 2003, Volume 8, pages 17-28
  3. ^ Shen, L. et al., Development of Autoimmunity in IL-14-Transgenic Mice. The Journal of Immunology, 2006, Volume 177, pages 5676-5686.


 
This article is licensed under the GNU Free Documentation License. It uses material from the Wikipedia article "Interleukin_14". A list of authors is available in Wikipedia.
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