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Interleukin 26



Interleukin 26
Identifiers
Symbol IL26
Alt. Symbols , AK155
Entrez 55801
HUGO 17119
OMIM 605679
RefSeq NM_018402
UniProt Q9NPH9
Other data
Locus Chr. 12 q15


Interleukin-26 (IL-26) is a 171-amino acid protein, which is similar in amino acid sequence to interleukin 10. It was originally called AK155 and is composed of a signal sequence, 6 helices, and 4 conserved cysteine residues. IL-26 is expressed in certain herpesvirus-transformed T cells but not in primary stimulated T cells.[1] IL-26 signals through a receptor complex comprising two distinct proteins called IL-20 receptor 1 and IL-10 receptor 2.[2] By signaling through this receptor complex, IL-26 induces rapid phosphorylation of the transcription factors STAT1 and STAT3, which enhance IL-10 and IL-8 secretion and as expression of the CD54 molecule on the surface of epithelial cells.[3]

Additional recommended knowledge

References

  1. ^ A. Knappe, et al., Induction of a novel cellular homolog of interleukin-10, AK155, by transformation of T lymphocytes with herpesvirus saimiri. Journal of Virolology, 2000, Volume 74, pages 3881-3887.
  2. ^ F. Sheikh, et al., IL-26 signals through a novel receptor complex composed of IL-20 receptor 1 and IL-10 receptor 2. Journal of Immunology, 2004, Volume 172, pages 2006-2010.
  3. ^ Hör S, Pirzer H, Dumoutier L, Bauer F, Wittmann S, Sticht H, Renauld J, de Waal Malefyt R, Fickenscher H (2004). "The T-cell lymphokine interleukin-26 targets epithelial cells through the interleukin-20 receptor 1 and interleukin-10 receptor 2 chains". J Biol Chem 279 (32): 33343-51. PMID 15178681.



 
This article is licensed under the GNU Free Documentation License. It uses material from the Wikipedia article "Interleukin_26". A list of authors is available in Wikipedia.
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