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Interleukin 16

Interleukin 16
Symbol IL16
Alt. Symbols LCF
Entrez 3603
HUGO 5980
OMIM 603035
RefSeq NP_004504
UniProt U82972
Other data
Locus Chr. 15 q26.3

Interleukin 16 (IL-16) is a cytokine that released by a variety of cells (including lymphocytes and some epithelial cells) that has been characterized as a chemoattractant for certain immune cells expressing the cell surface molecule CD4.

IL-16 was originally described as a factor that could attract activated T cells in humans, it was previously called lymphocyte chemoattractant factor (LCF). Since then, this interleukin has been shown to recruit and activate many other cells expressing the CD4 molecule, including monocytes, eosinophils, and dendritic cells.[1]

The structure of IL-16 was determined following its cloning in 1994. This cytokine is produced as a precursor peptide (pro-IL-16) that requires processing by an enzyme called caspase-3 to become active. CD4 is the cell signaling receptor for mature IL-16.


  1. ^ WW Cruikshank, H Kornfeld and DM Center, Interleukin-16, Journal of Leukocyte Biology, Volume 67, Issue 6, 2000, pages 757-766.
This article is licensed under the GNU Free Documentation License. It uses material from the Wikipedia article "Interleukin_16". A list of authors is available in Wikipedia.
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