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TCF7L2 also known as TCF4 is a protein acting as a transcription factor. A variant of the protein is linked to higher risk to develop type 2 diabetes.

Symbol TCF7L2
Alt. Symbols TCF4
Entrez 6934
HUGO 11641
OMIM 602228
RefSeq NM_030756.2
UniProt Q5JRY4
Other data
Locus Chr. 10 q25.3


TCF7L2 is a transcription factor influencing the transcription of several genes thereby exerting a large variety of functions in the cell. It is a member of the Wnt signaling pathway. Stimulation of the pathway leads to the association of β-catenin with TCF7L2 and BCL9 in the nucleus, which in turn results in the activation of Wnt target genes.

Disease implications

TCF7L2 is implied in a large variety of diseases. Several single nucleotide polymorphisms are associated with type 2 diabetes. In European populations it was found to be a major determinant of type 2 risk.

A frameshift mutation of TCF7L2 is implied in colorectal cancer. Variants of the gene are most likely involved in many other cancer types. See PubMed GeneRIFs for more information [1].


  • TCF7L2 here called TCF4 features on this Wnt pathway web site: Wnt signalling molecules TCFs
  • Structure determination of TCF7L2: PDB entry 2GL7 and related publication on PubMed
  • PubMed GeneRIFs (summaries of related scientific publications) - [2]
  • Weizmann Institute GeneCard for TCF7L2

This article is licensed under the GNU Free Documentation License. It uses material from the Wikipedia article "TCF7L2". A list of authors is available in Wikipedia.
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