ChemNavigator Announces New "Behind-the-Firewall" Use of iResearch System to Design Information-Biased Chemical Libraries

29-Jun-2001

ChemNavigator, providing life science organizations with advanced cheminformatics technologies, today announced an expanded use of its award-winning iResearch™ System for designing information-biased chemical compound libraries. Drug discovery researchers can now access a customized System behind their company's firewall to design biased libraries of commercially accessible, small-molecule compounds based on information specific to a research project, such as biological targets, disease areas, patents or toxicological profiles. "Traditional methods of analysis are too resource intensive for pharmaceutical companies to identify, gather and use available scientific information to bias chemical libraries for specific research projects," said Scott Hutton, president and CEO of ChemNavigator. "This new use of the iResearch System solves this significant problem faced by even the biggest pharmaceutical companies and provides a cost-effective way to mine vast compound collections in the pursuit of new drugs." The iResearch System includes the world's fastest and most comprehensive chemical search and comparison applications for retrieving billions of chemical-structure-comparison results in seconds. The System also supplements those results with dynamic links to relevant, hard-to-find, scientific information associated with each compound, such as cancer screening data, AIDS research, and scientific literature citations. "There are many publicly available scientific information sources, but most of them are hard to access, very disorganized, available in inconsistent formats, or just unknown to the researcher," said Hutton. "The iResearch System brings order to this world of supporting information and presents it to a researcher along with the compound library he or she is interested in." The newest use of ChemNavigator's iResearch System, recipient of this year's University of California at San Diego Connect's Most Innovative New Product Award, helps researchers by performing the following functions: Define the scientific and business rules of a research project, thereby creating a unique "project chemistry space" Populate the project chemistry space with commercially accessible screening compounds that are consistent with the established rules Link each compound in the project chemistry space with relevant scientific-information records harvested by ChemNavigator from sources on the Internet Update the information in the project chemistry space through a secure, live Internet feed as the data landscape changes The iResearch System Library, which is a major component of the System, contains over 1.8 million commercially accessible compounds from 30 international chemistry suppliers. In addition to linking compound collections with external sources, the iResearch System also allows for proprietary information to be incorporated into a project, thereby combining the results with an internal knowledge base. One of the strongest selling points is the simplicity of the iResearch System, which easily integrates with existing infrastructures and is highly automated. "The new service puts valuable information in the hands of scientists. In addition, the System keeps that information up to date so that scientists can concentrate on other research activities," said Tad Hurst, vice president and CTO of ChemNavigator. In addition to designing custom libraries, ChemNavigator continues to offer a number of paid membership plans to access the compound search-and-source application of the iResearch System through an Internet-based application. Members have access to the 1.8 million compound iResearch System Library and ChemNavigator's growing list of over 30 chemistry suppliers. ChemNavigator makes available its Chemistry Alert Agent™, which searches for new, hard-to-find compounds related to a user's area of

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