Chenomx, Inc. and Varian, Inc. Form Distribution Relationship For 'Eclipse' Metabolite-Profiling Software

24-Sep-2003

Varian, Inc. and Chenomx, Inc., a leader in the rapidly growing field of metabolic profiling, announced that they have entered into a distribution agreement to market Chenomx's "Eclipse" bioprofiling software, which can be used with data acquired from Varian, Inc. 400 MHz - 700 MHz NMR spectrometers.

Metabolic profiling, or metabonomics, is the study of low molecular weight chemicals, known as metabolites, found in a living organism. Metabolite levels can differ due to a variety of effects, such as drug ingestion, hence metabolic profiling is used to evaluate the efficacy or toxicity of drug candidates, helping researchers develop safer and more effective pharmaceuticals. NMR data can be particularly informative, as the metabolites in a bio-fluid sample can be viewed and quantified with just one experiment. When this information is gathered from a number of samples, it can be used to generate a series of metabolic profiles that correspond to different drugs, diseases or other causes of biochemical change.

Chenomx's "Eclipse" software uses proprietary mathematical algorithms to separate the individual metabolite signals from the mixture of metabolites that occur in urine or blood. It then analyzes the separate components using sophisticated databases. When combined with NMR spectra generated by Varian, Inc. spectrometers, this provides a one-step analysis that can correlate with a drug's efficacy or toxicity. Varian, Inc.'s NMR spectrometers are well-known for their sensitivity and flexibility and are used for a broad number of small molecule and proteomics applications.

Other Varian, Inc. instrumentation, including LC-NMR/MS, UV-Vis, photo diode array, mass spectrometers and NMR spectrometers, can be used with the overall metabolic profiling process to help identify unknown or low concentration compounds within the biofluid. Each individual metabolite found can be added to the existing databases, enhancing the quantitative capability of the Chenomx software.

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Investigation with spectroscopy gives us unique insights into the composition and structure of materials. From UV-Vis spectroscopy to infrared and Raman spectroscopy to fluorescence and atomic absorption spectroscopy, spectroscopy offers us a wide range of analytical techniques to precisely characterize substances. Immerse yourself in the fascinating world of spectroscopy!

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