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Acetorphine



Acetorphine
Systematic (IUPAC) name
4,5α-epoxy-7α-(1-hydroxy-1-methylbutyl)-6-methoxy -17-methyl-6,14-endo-ethenomorphinan-3-yl acetate
Identifiers
CAS number 25333-77-1
ATC code  ?
PubChem 62795
Chemical data
Formula C27H35NO5 
Mol. mass 453.57 g/mol
Pharmacokinetic data
Bioavailability  ?
Metabolism  ?
Half life  ?
Excretion  ?
Therapeutic considerations
Pregnancy cat.

?

Legal status

Schedule II

Routes  ?

Acetorphine is a potent analgesic drug (painkiller), several thousand times stronger than morphine by weight. It is a derivative of the more well-known opioid etorphine, which is used as a very potent veterinary painkiller and anesthetic medication, primarily for the sedation of large animals such as elephants, giraffes and rhinos.

Additional recommended knowledge

Acetorphine was developed in 1966 by the Reckitt research group that developed etorphine. Acetorphine was developed for the same purpose as etorphine itself, namely as a strong tranquillizer for use in immobilizing large animals in veterinary medicine. However despite showing some advantages over etorphine (for instance producing less toxic side effects in giraffes), acetorphine was never widely adopted for veterinary use, and etorphine (along with other tranquillizers such as carfentanil and azaperone) remains the drug of choice in this application.



References

    UN Office on Drugs and Crime. Bulletin on Narcotics 1968, page 51-52

     
    This article is licensed under the GNU Free Documentation License. It uses material from the Wikipedia article "Acetorphine". A list of authors is available in Wikipedia.
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