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PEPAP



PEPAP
Systematic (IUPAC) name
[4-phenyl-1-(2-phenylethyl)piperidin-4-yl] acetate
Identifiers
CAS number 64-52-8
ATC code  ?
PubChem 60977
Chemical data
Formula C21H25NO2 
Mol. mass 323.43 g/mol
Synonyms PEPAP
Pharmacokinetic data
Bioavailability  ?
Metabolism  ?
Half life  ?
Excretion  ?
Therapeutic considerations
Pregnancy cat.

?

Legal status

Class A(UK) Schedule I(US)

Routes  ?

PEPAP is an opioid analgesic that is an analogue of pethidine (meperidine).

Additional recommended knowledge

It is related to the drug MPPP, with a phenethyl group in place of the 1-methyl substitution and an acetate ester rather than propionate.

PEPAP presumably has similar effects to other opioids, producing analgesia, sedation and euphoria. Side effects can include itching, nausea and potentially serious respiratory depression which can be life-threatening.

PEPAP could be particularly dangerous as it has been found to be a potent CYP2D6 inhibitor, which makes it likely to cause adverse interactions with some other drugs.[1]

It is however not known whether the byproducts formed during the synthesis of PEPAP are neurotoxic in the same way as the MPPP byproduct MPTP.


References

  1. ^ Pritzker D, Kanungo A, Kilicarslan T, Tyndale RF, Sellers EM. Designer drugs that are potent inhibitors of CYP2D6. Journal of Clinical Psychopharmacology. 2002 Jun;22(3):330-2.


 
This article is licensed under the GNU Free Documentation License. It uses material from the Wikipedia article "PEPAP". A list of authors is available in Wikipedia.
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