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Picenadol (LY-150720) is a 4-phenylpiperidine derivative that is an opioid analgesic drug.
Additional recommended knowledge
Picenadol is an effective analgesic with similar efficacy to pethidine (meperidine). It has been investigated for some applications such as obstetrics and dentistry, but never commercialised.
It is unusual in that one enantiomer is a pure μ-opioid agonist, while the other is an antagonist. The (3R,4R) isomer is the agonist, while (3S,4S) is antagonist. This means that the racemic mix of the two enantiomers is a mixed agonist-antagonist, with relatively low abuse potential, and little of the κ-opioid activity that tends to cause problems with other opioid mixed agonist-antagonists such as pentazocine.
|This article is licensed under the GNU Free Documentation License. It uses material from the Wikipedia article "Picenadol". A list of authors is available in Wikipedia.|