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Lefetamine



Lefetamine
Systematic (IUPAC) name
(R)-N,N-dimethyl-1,2-diphenyl-ethanamine
Identifiers
CAS number 7262-75-1
ATC code  ?
PubChem  ?
Chemical data
Formula C16H19N 
Mol. mass 225.329 g/mol
Synonyms Lefetamine, Santenol, SPA, (-)-N,N-dimethyl-1,2-diphenylethylamine
Pharmacokinetic data
Bioavailability  ?
Metabolism  ?
Half life  ?
Excretion  ?
Therapeutic considerations
Pregnancy cat.

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Legal status
Routes  ?

Lefetamine (Santenol) is a psychoactive drug which is both a stimulant and an analgesic with effects comparable to both morphine and methylphenidate.

Additional recommended knowledge

Lefetamine was invented in the 1940s[1] and was widely abused in Japan [2] during the 1950s. [3] It has been researched for medicinal use but showed little advantage over other analgesics, although it did seem promising for treating opiate withdrawal it was not as good as buprenorphine for this purpose. [4] More recently it has been abused in Europe, but it remains an obscure drug on the illicit market.

Due to its chemical structure, it binds to opioid receptors while simultaneously inhibiting reuptake of dopamine and norepinephrine.[5] Lefetamine has the necessary tertiary amine functional group required for opioid receptor recognition, as well as a phenethylamine skeleton (which is responsible for its amphetamine-like effects). [6] It is also reported to have some NMDA antagonist effects and to have neurotoxic properties. [7]

Boiling Point: 142-147° C

Optical Rotation: [α]D20 -124.2° (ethanol).

CAS number of hydrochloride: 14148-99-3


References

  1. ^ Dodds EC, Lawson W, Simpson SA, Williams PC. Testing diphenylethylamine compounds for analgesic action. Journal of Physiology (1945); (104):47-51.
  2. ^ K. Ogiu et al., J. Pharm. Soc. Japan 80, 283 (1960)
  3. ^ Mannelli P, Janiri L, De Marinis M, Tempesta E. Lefetamine: new abuse of an old drug--clinical evaluation of opioid activity. Drug and Alcohol Dependence. 1989 Oct;24(2):95-101.
  4. ^ Janiri L, Mannelli P, Persico AM, Serretti A, Tempesta E. Opiate detoxification of methadone maintenance patients using lefetamine, clonidine and buprenorphine. Drug and Alcohol Dependence. 1994 Oct;36(2):139-45.
  5. ^ Janiri L, Mannelli P, Pirrongelli C, Lo Monaco M, Tempesta E. Lephetamine abuse and dependence: clinical effects and withdrawal syndrome. British Journal of Addiction. 1989 Jan;84(1):89-95.
  6. ^ Massa S, Di Santo R, Mai A, Artico M, Pantaleoni GC, Giorgi R, Coppolino MF. Pyrrylphenylethanones related to cathinone and lefetamine: synthesis and pharmacological activities. Archiv der Pharmazie (Weinheim). 1992 Jul;325(7):403-9.
  7. ^ Massa S, Stefancich G, Artico M, Corelli F, Silvestri R, Pantaleoni GC, Fanini D, Palumbo G, Giorgi R. Synthesis, neuropsychopharmacological effects and analgesic-antiinflammatory activities of pyrrole analogues of lefetamine. Farmaco. 1989 Sep;44(9):763-77.


See also

 
This article is licensed under the GNU Free Documentation License. It uses material from the Wikipedia article "Lefetamine". A list of authors is available in Wikipedia.
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