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Alvimopan



Alvimopan
Systematic (IUPAC) name
2-([(2S)-2-([(3R,4R)-4-(3-hydroxyphenyl)-3,4-dimethylpiperidin-1-yl]methyl) -3-phenylpropanoyl]amino)acetic acid
Identifiers
CAS number 156053-89-3
ATC code  ?
PubChem 5488548
Chemical data
Formula C25H32N2O4 
Mol. mass 424.53 g/mol
Synonyms Alvimopan, Entereg
Pharmacokinetic data
Bioavailability  ?
Metabolism  ?
Half life  ?
Excretion  ?
Therapeutic considerations
Pregnancy cat.

?

Legal status
Routes  ?

Alvimopan (Entereg) is a drug which behaves as a peripherally acting μ-opioid antagonist. With limited ability to cross the blood-brain barrier, many of the undesirable side-effects of the opioid agonists such as constipation are minimized without affecting analgesia or precipitating withdrawals.

Additional recommended knowledge



References

    • Neary P, Delaney P (2005). "Alvimopan". Expert Opin Investig Drugs 14 (4): 479-88. PMID 15882122.
    • Schmidt WK (2001). "Alvimopan* (ADL 8-2698) is a novel peripheral opioid antagonist". Am J Surg 182 (5A Supp): 27S-38S. PMID 11755894.


     
    This article is licensed under the GNU Free Documentation License. It uses material from the Wikipedia article "Alvimopan". A list of authors is available in Wikipedia.
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