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Ethoheptazine



Ethoheptazine
Systematic (IUPAC) name
ethyl 1-methyl-4-phenylazepane-4-carboxylate
Identifiers
CAS number 77-15-6
ATC code  ?
PubChem 6469
Chemical data
Formula C16H23NO2 
Mol. mass 261.36 g/mol
Synonyms Ethoheptazine, Zactane, Equagesic
Pharmacokinetic data
Bioavailability  ?
Metabolism  ?
Half life  ?
Excretion  ?
Therapeutic considerations
Pregnancy cat.

?

Legal status

Schedule V(US)

Routes  ?

Ethoheptazine (Zactane, Equagesic) is an opioid analgesic from the phenazepine family. It was invented in the 1950s[1] and is related to other drugs such as proheptazine.[2]

Additional recommended knowledge

Ethoheptazine produces similar effects to other opioids, including analgesia, sedation, dizziness and nausea.[3] It was sold by itself as Zactane, and is still available as a combination product with acetylsalicylic acid and meprobamate as Equagesic, which is used for the treatment of conditions where both pain and anxiety are present.[4][1]




References

  1. ^ Batterman RC, Golbey M, Grossman AJ, Leifer P. Analgesic effectiveness of orally administered ethoheptazine in man. American Journal of Medical Sciences. 1957 Oct;234(4):413-9.
  2. ^ Diamond J, Bruce WF, Tyson FT. Synthesis and Properties of the Analgesic DL-α-1,3-dimethyl-4-phenyl-4-propionoxyazacycloheptane (Proheptazine). Journal of Medicinal Chemistry. 1964 Jan;7:57-60.
  3. ^ Cinelli P, Zucchini M. Current pharmaco-therapeutic possiblities in the treatment of pain. Experiments with ethoeptazine. (Italian). Minerva Medica. 1962 Mar 3;53:637-42.
  4. ^ Scheiner JJ, Richards DJ. Treatment of musculoskeletal pain and associated anxiety with an ethoheptazine-aspirin-meprobamate combination (equagesic): a controlled study. Current Therapeutic Research, Clinical and Experimental. 1974 Sep;16(9):928-36.


 
This article is licensed under the GNU Free Documentation License. It uses material from the Wikipedia article "Ethoheptazine". A list of authors is available in Wikipedia.
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