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Systematic (IUPAC) name
1-[2-(4-chlorophenyl)ethyl]-6,7-dimethoxy -2-methyl-3,4-dihydro-1H-isoquinoline
CAS number 2154-02-1
ATC code  ?
PubChem 16538
Chemical data
Formula C20H24ClNO2 
Mol. mass 345.87 g/mol
Synonyms Methopholine
Pharmacokinetic data
Bioavailability  ?
Metabolism  ?
Half life  ?
Excretion  ?
Therapeutic considerations
Pregnancy cat.


Legal status


Routes  ?

Methopholine is an opioid analgesic drug invented in the 1960s.

Methopholine is an isoquinoline derivative which is not structurally related to most other opioids.[1] It has around the same efficacy as an analgesic as codeine, and was evaluated for the treatment of postoperative pain, but never commercialised.[2][3][4]

Methopholine is legal throughout the world.


  1. ^ Feinberg AP, Creese I, Snyder SH. The opiate receptor: a model explaining structure-activity relationships of opiate agonists and antagonists. Proceedings of the National Academy of Sciences U S A. 1976 Nov;73(11):4215-9.
  2. ^ Moore J, Foldes FF, Davidson GM. An evaluation of the efficacy of methopholine for the relief of postoperative pain. American Journal of Medical Sciences. 1962 Sep;244:337-43.
  3. ^ Cass LJ, Frederik WS. Methopholine, A New Analgesic Agent. American Journal of Medical Sciences. 1963 Nov;246:550-7.
  4. ^ Sciorelli G. Plasma levels and renal excretion of unchanged methopholine in man. Experientia. 1967 Nov 15;23(11):934-6.
This article is licensed under the GNU Free Documentation License. It uses material from the Wikipedia article "Methopholine". A list of authors is available in Wikipedia.
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