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Etonitazene



Etonitazene
Systematic (IUPAC) name
2-(p-Ethoxybenzyl)-1-diethylaminoethyl-5-nitrobenzimidazole
Identifiers
CAS number 911-65-9
ATC code  ?
PubChem 13493
Chemical data
Formula C22H28N4O3 
Mol. mass 396.48 g/mol
Pharmacokinetic data
Bioavailability  ?
Metabolism  ?
Half life  ?
Excretion  ?
Therapeutic considerations
Pregnancy cat.

?

Legal status

Schedule I(CA) Schedule I(US)

Routes  ?

Etonitazene is a highly potent narcotic analgesic (1000–1500x morphine). It's the one of several benzimidazole opioids, and is structurally related to clonitazene (where the p-ethoxybenzyl group is replaced by a p-chlorobenzyl group. However, clonitazene itself has only 3x the potency of morphine.).

Additional recommended knowledge

It has a strong dependency potential similar to that of morphine and therefore is not used in humans. It is, however, useful in addiction studies on animals.

It is the most potent benzimidazole opioid currently known.[1] Other analogues of considerable potency are as follows:

  • Methyl (10x morphine)
  • Ethyl (30x morphine)
  • Propyl (50x morphine)
  • Methoxy (100x morphine)
  • Isopropoxy (500x morphine)
  • Butoxy (200x morphine)
  • Methylthio (50x morphine)
  • Ethylthio (30x morphine)

These groups replace the p-ethoxy group - there are other possible modifications but these are the most significant.

The drug has proved very important in mapping out the opiate receptor and some experimental compounds in which phenolic groupings have been replaced with nitro groupings have proved more active than the parent compound.[citation needed]

Illicit production and sale of etonitazene has been limited. This compound was identified on the illegal drug market in Moscow in 1998, appeared to have been illicitly manufactured, and was primarily smoked.[1] In another case a chemist at Morton Thiokol called Thomas K Highsmith Hovey [2] produced the compound and placed it in a nasal inhaler. Such was the level of his addiction, insufficient amounts of methadone were given and he committed suicide before the case went to court[citation needed]

References

  1. ^ Sorokin VI, Ponkratov KV, Drozdov MA. Etonitazene Encountered in Moscow. MICROGRAM 1999; 32(9): 239-244
  2. ^ http://findarticles.com/p/articles/mi_qn4188/is_20030603/ai_n11394964



 
This article is licensed under the GNU Free Documentation License. It uses material from the Wikipedia article "Etonitazene". A list of authors is available in Wikipedia.
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